Mysteries of Metals in Metalloenzymes
نویسندگان
چکیده
منابع مشابه
Surprising cofactors in metalloenzymes.
Transition metal complexes are located at the active sites of a number of enzymes involved in intriguing biochemical reactions. These complexes can exhibit a wide variety of chemical reactivity due to the ease at which transition metals can adopt different coordination environments and oxidation states. Crystallography has been a powerful technique for examining the structure and conformational...
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چکیده ندارد.
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Understanding the early genesis of new enzymatic functions is one of the challenges in protein design, mechanistic enzymology, and molecular evolution. We have experimentally mimicked starting points in this process by introducing primitive iron and oxygen binding sites at various locations in thioredoxin, a small protein lacking metal centers, by using computational design. These rudimentary a...
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in vitro and in vivo can be attributed to crowding? The answer to this question depends upon the particular reaction and the microscopic environment in which the reaction is taking place. Early demonstrations of the large effect of crowding on association equilibria and rates were based upon studies of the behavior of mutant and normal hemoglobins in erythrocytes. Hemolysate is a fairly simple ...
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2014
ISSN: 0001-4842,1520-4898
DOI: 10.1021/ar500227u